Assay Detail
Binding
CHEMBL827381
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity for Dopamine receptor D2
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 5.69 | 6.63 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL369477 | — | — | 1 | 6.63 |
| CHEMBL361179 | — | — | 1 | 6.59 |
| CHEMBL368926 | — | — | 1 | 6.18 |
| CHEMBL298406 | ECOPIPAM | 3.0 | 1 | 6.01 |
| CHEMBL367108 | — | — | 1 | 6.01 |
| CHEMBL62 | SCH-23390 | — | 1 | 6.00 |
| CHEMBL368482 | — | — | 1 | 5.99 |
| CHEMBL177896 | — | — | 1 | 5.98 |
| CHEMBL366347 | — | — | 1 | 5.86 |
| CHEMBL359696 | — | — | 1 | 5.82 |
| CHEMBL367020 | — | — | 1 | 5.54 |
| CHEMBL179215 | — | — | 1 | 5.52 |
| CHEMBL177267 | — | — | 1 | 5.50 |
| CHEMBL366839 | — | — | 1 | 5.49 |
| CHEMBL180059 | — | — | 1 | 5.45 |
| CHEMBL366569 | — | — | 1 | 5.30 |
| CHEMBL359605 | — | — | 1 | 5.00 |
| CHEMBL177331 | — | — | 1 | 5.00 |
| CHEMBL175965 | — | — | 1 | 5.00 |
| CHEMBL424776 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL369477 | — | Ki | = | 232.0 | nM | 6.63 |
| CHEMBL361179 | — | Ki | = | 257.0 | nM | 6.59 |
| CHEMBL368926 | — | Ki | = | 661.0 | nM | 6.18 |
| CHEMBL298406 | ECOPIPAM | Ki | = | 980.0 | nM | 6.01 |
| CHEMBL367108 | — | Ki | = | 984.0 | nM | 6.01 |
| CHEMBL62 | SCH-23390 | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL368482 | — | Ki | = | 1023.0 | nM | 5.99 |
| CHEMBL177896 | — | Ki | = | 1040.0 | nM | 5.98 |
| CHEMBL366347 | — | Ki | = | 1390.0 | nM | 5.86 |
| CHEMBL359696 | — | Ki | = | 1530.0 | nM | 5.82 |
| CHEMBL367020 | — | Ki | = | 2890.0 | nM | 5.54 |
| CHEMBL179215 | — | Ki | = | 3000.0 | nM | 5.52 |
| CHEMBL177267 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL366839 | — | Ki | = | 3270.0 | nM | 5.49 |
| CHEMBL180059 | — | Ki | = | 3550.0 | nM | 5.45 |
| CHEMBL366569 | — | Ki | = | 5010.0 | nM | 5.30 |
| CHEMBL359605 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL177331 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL175965 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL424776 | — | Ki | = | 10000.0 | nM | 5.00 |