Assay Detail
Binding
CHEMBL827382
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In vitro binding affinity for Dopamine receptor D4
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Dopamine D1/D5 receptor antagonists with improved pharmacokinetics: design, synthesis, and biological evaluation of phenol bioisosteric analogues of benzazepine D1/D5 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 5.04 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL298406 | ECOPIPAM | 3.0 | 1 | 5.26 |
| CHEMBL368482 | — | — | 1 | 5.00 |
| CHEMBL366839 | — | — | 1 | 5.00 |
| CHEMBL361179 | — | — | 1 | 5.00 |
| CHEMBL368926 | — | — | 1 | 5.00 |
| CHEMBL180059 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL298406 | ECOPIPAM | Ki | = | 5520.0 | nM | 5.26 |
| CHEMBL368482 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL366839 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL361179 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL368926 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL180059 | — | Ki | = | 10000.0 | nM | 5.00 |