Assay Detail
Binding
CHEMBL827396
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Apparent Ki against human aromatase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and aromatase inhibitory activity of novel pyridine-containing isoflavones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.98 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188664 | — | — | 1 | 6.66 |
| CHEMBL187068 | — | — | 1 | 6.58 |
| CHEMBL185950 | — | — | 1 | 6.51 |
| CHEMBL185809 | — | — | 1 | 6.05 |
| CHEMBL184051 | — | — | 1 | 5.94 |
| CHEMBL488 | AMINOGLUTETHIMIDE | 4.0 | 1 | 5.85 |
| CHEMBL361653 | — | — | 1 | 5.77 |
| CHEMBL117 | CHRYSIN | — | 1 | 5.58 |
| CHEMBL131921 | BIOCHANIN | — | 1 | 4.92 |
| CHEMBL44 | GENISTEIN | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188664 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL187068 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL185950 | — | Ki | = | 310.0 | nM | 6.51 |
| CHEMBL185809 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL184051 | — | Ki | = | 1160.0 | nM | 5.94 |
| CHEMBL488 | AMINOGLUTETHIMIDE | Ki | = | 1410.0 | nM | 5.85 |
| CHEMBL361653 | — | Ki | = | 1690.0 | nM | 5.77 |
| CHEMBL117 | CHRYSIN | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL131921 | BIOCHANIN | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL44 | GENISTEIN | Ki | = | 123000.0 | nM | - |