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Assay Detail

CHEMBL827419

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Mitogenic stimulation or antagonism of 30 nM quinpirole-stimulated mitogenesis in CHO cells expressing human dopamine D2 receptor
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CHO
Confidence 9 — Direct single protein target
Curated By Expert

Target

D(2) dopamine receptor (CHEMBL217)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents.
Newman AH, Grundt P, Nader MA.
J Med Chem (2005) 48 : 3663 -3679
PubMed 15916415 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 7.24 8.13

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL71865 1 8.13
CHEMBL195057 1 8.08
CHEMBL194493 1 7.86
CHEMBL301242 2 7.84
CHEMBL71327 1 7.79
CHEMBL302374 1 7.26
CHEMBL370713 1 7.21
CHEMBL262724 1 7.12
CHEMBL180010 1 7.09
CHEMBL69451 1 7.04
CHEMBL59725 1 7.02
CHEMBL366904 1 6.96
CHEMBL139926 1 6.93
CHEMBL180060 1 6.79
CHEMBL175734 1 6.59
CHEMBL300780 1 5.89

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL71865 IC50 = 7.49 nM 8.13
CHEMBL195057 IC50 = 8.29 nM 8.08
CHEMBL194493 IC50 = 13.8 nM 7.86
CHEMBL301242 IC50 = 14.6 nM 7.84
CHEMBL71327 IC50 = 16.1 nM 7.79
CHEMBL301242 IC50 = 35.6 nM 7.45
CHEMBL302374 IC50 = 55.4 nM 7.26
CHEMBL370713 IC50 = 61.8 nM 7.21
CHEMBL262724 IC50 = 76.7 nM 7.12
CHEMBL180010 IC50 = 80.9 nM 7.09
CHEMBL69451 IC50 = 92.0 nM 7.04
CHEMBL59725 IC50 = 94.7 nM 7.02
CHEMBL366904 IC50 = 111.0 nM 6.96
CHEMBL139926 IC50 = 118.0 nM 6.93
CHEMBL180060 IC50 = 162.0 nM 6.79
CHEMBL175734 IC50 = 254.0 nM 6.59
CHEMBL300780 IC50 = 1280.0 nM 5.89