Assay Detail
Functional
CHEMBL827507
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VEGF-stimulated human umbilical vein endothelial cell proliferation
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Endothelial cell |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Vascular endothelial growth factor receptor (CHEMBL2095227) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Synthesis and structure-activity relationships of soluble 7-substituted 3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-2-amines and related ureas as dual inhibitors of the fibroblast growth factor receptor-1 and vascular endothelial growth factor receptor-2 tyrosine kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.76 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339856 | — | — | 1 | 7.43 |
| CHEMBL425363 | — | — | 1 | 7.39 |
| CHEMBL191023 | — | — | 1 | 7.37 |
| CHEMBL365727 | — | — | 1 | 7.33 |
| CHEMBL278472 | — | — | 1 | 7.33 |
| CHEMBL190161 | — | — | 1 | 7.18 |
| CHEMBL189995 | — | — | 1 | 7.14 |
| CHEMBL187396 | — | — | 1 | 7.09 |
| CHEMBL191070 | — | — | 1 | 7.04 |
| CHEMBL192856 | — | — | 1 | 6.72 |
| CHEMBL189584 | PD-173074 | — | 1 | 6.72 |
| CHEMBL189059 | — | — | 1 | 6.66 |
| CHEMBL363551 | — | — | 1 | 6.55 |
| CHEMBL190389 | — | — | 1 | 6.28 |
| CHEMBL188087 | — | — | 1 | 6.06 |
| CHEMBL189851 | — | — | 1 | 6.03 |
| CHEMBL190783 | — | — | 1 | 5.75 |
| CHEMBL365140 | — | — | 1 | 5.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339856 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL425363 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL191023 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL365727 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL278472 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL190161 | — | IC50 | = | 66.0 | nM | 7.18 |
| CHEMBL189995 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL187396 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL191070 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL192856 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL189584 | PD-173074 | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL189059 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL363551 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL190389 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL188087 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL189851 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL190783 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL365140 | — | IC50 | = | 3000.0 | nM | 5.52 |