Assay Detail
Binding
CHEMBL827764
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Haemophilus influenzae beta-Ketoacyl-acyl carrier protein synthase III
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Haemophilus influenzae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Beta-ketoacyl-[acyl-carrier-protein] synthase III (CHEMBL3822) ↗| Type | SINGLE PROTEIN |
| Organism | Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) |
Publication
Structure-based design, synthesis, and study of potent inhibitors of beta-ketoacyl-acyl carrier protein synthase III as potential antimicrobial agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.16 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL370931 | — | — | 1 | 5.62 |
| CHEMBL191827 | — | — | 1 | 4.70 |
| CHEMBL175848 | — | — | 1 | - |
| CHEMBL180466 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL370931 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL191827 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL175848 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL180466 | — | IC50 | > | 100000.0 | nM | - |