Assay Detail
Binding
CHEMBL827786
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Inhibition of human Glycogen synthase kinase-3 beta
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
4-Acylamino-6-arylfuro[2,3-d]pyrimidines: potent and selective glycogen synthase kinase-3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.66 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361196 | — | — | 1 | 8.30 |
| CHEMBL182419 | — | — | 1 | 8.30 |
| CHEMBL183038 | — | — | 1 | 7.70 |
| CHEMBL181959 | — | — | 1 | 7.52 |
| CHEMBL361567 | — | — | 1 | 7.10 |
| CHEMBL183077 | — | — | 1 | 6.89 |
| CHEMBL360534 | — | — | 1 | 6.77 |
| CHEMBL185922 | — | — | 1 | 6.66 |
| CHEMBL182007 | — | — | 1 | 6.62 |
| CHEMBL362030 | — | — | 1 | 6.50 |
| CHEMBL182891 | — | — | 1 | 6.50 |
| CHEMBL360878 | — | — | 1 | 6.36 |
| CHEMBL182560 | — | — | 1 | 6.27 |
| CHEMBL183171 | — | — | 1 | 6.26 |
| CHEMBL183504 | — | — | 1 | 6.24 |
| CHEMBL182283 | GW819230X | — | 1 | 6.21 |
| CHEMBL182904 | — | — | 1 | 6.00 |
| CHEMBL360340 | — | — | 1 | 5.74 |
| CHEMBL181856 | — | — | 1 | 5.71 |
| CHEMBL183742 | — | — | 1 | 5.62 |
| CHEMBL427325 | — | — | 1 | - |
| CHEMBL181147 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361196 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL182419 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL183038 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL181959 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL361567 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL183077 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL360534 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL185922 | — | IC50 | = | 219.0 | nM | 6.66 |
| CHEMBL182007 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL362030 | — | IC50 | = | 316.0 | nM | 6.50 |
| CHEMBL182891 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL360878 | — | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL182560 | — | IC50 | = | 537.0 | nM | 6.27 |
| CHEMBL183171 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL183504 | — | IC50 | = | 575.0 | nM | 6.24 |
| CHEMBL182283 | GW819230X | IC50 | = | 617.0 | nM | 6.21 |
| CHEMBL182904 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL360340 | — | IC50 | = | 1820.0 | nM | 5.74 |
| CHEMBL181856 | — | IC50 | = | 1950.0 | nM | 5.71 |
| CHEMBL183742 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL427325 | — | IC50 | > | 35000.0 | nM | - |
| CHEMBL181147 | — | IC50 | > | 34000.0 | nM | - |