Assay Detail
Binding
CHEMBL827789
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Inhibition of insulin Receptor kinase
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.39 | 5.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL177688 | — | — | 1 | 5.77 |
| CHEMBL188502 | — | — | 1 | 5.00 |
| CHEMBL372657 | — | — | 1 | - |
| CHEMBL188386 | — | — | 1 | - |
| CHEMBL190984 | — | — | 1 | - |
| CHEMBL371169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL177688 | — | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL188502 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL372657 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL188386 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL190984 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL371169 | — | IC50 | > | 10000.0 | nM | - |