Assay Detail
Binding
CHEMBL827820
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against Toxoplasma gondii DHFR
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.06 | 9.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190650 | — | — | 1 | 9.34 |
| CHEMBL189952 | — | — | 1 | 8.72 |
| CHEMBL188540 | — | — | 1 | 8.70 |
| CHEMBL190199 | — | — | 1 | 8.64 |
| CHEMBL190486 | — | — | 1 | 8.64 |
| CHEMBL192835 | — | — | 1 | 8.49 |
| CHEMBL189796 | — | — | 1 | 8.47 |
| CHEMBL370239 | — | — | 1 | 8.39 |
| CHEMBL187570 | — | — | 1 | 8.39 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 8.37 |
| CHEMBL425893 | — | — | 1 | 8.37 |
| CHEMBL187595 | — | — | 1 | 8.24 |
| CHEMBL190026 | — | — | 1 | 8.24 |
| CHEMBL190935 | — | — | 1 | 8.00 |
| CHEMBL189953 | — | — | 1 | 7.96 |
| CHEMBL435938 | — | — | 1 | 7.89 |
| CHEMBL191071 | — | — | 1 | 7.82 |
| CHEMBL190340 | — | — | 1 | 7.80 |
| CHEMBL189012 | — | — | 1 | 7.68 |
| CHEMBL300419 | — | — | 1 | 7.47 |
| CHEMBL189369 | — | — | 1 | 7.11 |
| CHEMBL190807 | — | — | 1 | 7.00 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 5.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190650 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL189952 | — | IC50 | = | 1.9 | nM | 8.72 |
| CHEMBL188540 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL190199 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL190486 | — | IC50 | = | 2.3 | nM | 8.64 |
| CHEMBL192835 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL189796 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL370239 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL187570 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL425893 | — | IC50 | = | 4.3 | nM | 8.37 |
| CHEMBL187595 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL190026 | — | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL190935 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL189953 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL435938 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL191071 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL190340 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL189012 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL300419 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL189369 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL190807 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 2800.0 | nM | 5.55 |