Assay Detail
Binding
CHEMBL827857
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against human plasma mu-calpain
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Plasma |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of chromone carboxamides as calpain inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.87 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL423112 | — | — | 1 | 6.70 |
| CHEMBL195728 | — | — | 1 | 6.62 |
| CHEMBL196671 | — | — | 1 | 6.35 |
| CHEMBL382711 | — | — | 1 | 6.28 |
| CHEMBL195992 | — | — | 1 | 6.14 |
| CHEMBL382964 | — | — | 1 | 6.09 |
| CHEMBL196113 | — | — | 1 | 5.61 |
| CHEMBL196990 | — | — | 1 | 5.34 |
| CHEMBL197415 | — | — | 1 | 5.25 |
| CHEMBL197420 | — | — | 1 | 5.09 |
| CHEMBL193345 | — | — | 1 | 5.06 |
| CHEMBL196184 | — | — | 1 | - |
| CHEMBL274229 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL423112 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL195728 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL196671 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL382711 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL195992 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL382964 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL196113 | — | IC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL196990 | — | IC50 | = | 4530.0 | nM | 5.34 |
| CHEMBL197415 | — | IC50 | = | 5690.0 | nM | 5.25 |
| CHEMBL197420 | — | IC50 | = | 8170.0 | nM | 5.09 |
| CHEMBL193345 | — | IC50 | = | 8730.0 | nM | 5.06 |
| CHEMBL196184 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL274229 | — | IC50 | > | 20000.0 | nM | - |