Assay Detail
Binding
CHEMBL827933
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Inhibitory concentration against recombinant Falcipain-2
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.94 | 8.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191881 | LEUPEPTIN | — | 1 | 8.24 |
| CHEMBL374508 | E-64 | — | 1 | 7.24 |
| CHEMBL192149 | — | — | 1 | 5.75 |
| CHEMBL195381 | — | — | 1 | 5.60 |
| CHEMBL195822 | — | — | 1 | 5.60 |
| CHEMBL194821 | — | — | 1 | 5.58 |
| CHEMBL191640 | — | — | 1 | 5.58 |
| CHEMBL373022 | — | — | 1 | 5.47 |
| CHEMBL191457 | — | — | 1 | 5.42 |
| CHEMBL370877 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191881 | LEUPEPTIN | IC50 | = | 5.8 | nM | 8.24 |
| CHEMBL374508 | E-64 | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL192149 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL195381 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL195822 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL194821 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL191640 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL373022 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL191457 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL370877 | — | IC50 | = | 12500.0 | nM | 4.90 |