Assay Detail
Binding
CHEMBL828014
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Inhibition of [125I]IABN binding to human Dopamine D4 receptor expressed in HEK 293 cells
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Dopamine D3 receptor partial agonists and antagonists as potential drug abuse therapeutic agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.16 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69571 | — | — | 1 | 6.44 |
| CHEMBL180010 | — | — | 1 | 6.43 |
| CHEMBL304605 | — | — | 1 | 5.99 |
| CHEMBL366904 | — | — | 1 | 5.97 |
| CHEMBL301242 | — | — | 1 | 5.95 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69571 | — | Ki | = | 363.0 | nM | 6.44 |
| CHEMBL180010 | — | Ki | = | 375.0 | nM | 6.43 |
| CHEMBL304605 | — | Ki | = | 1020.0 | nM | 5.99 |
| CHEMBL366904 | — | Ki | = | 1070.0 | nM | 5.97 |
| CHEMBL301242 | — | Ki | = | 1116.0 | nM | 5.95 |