Assay Detail
Binding
CHEMBL828038
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human vascular endothelial growth factor receptor 2 (Flk-1)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design, synthesis, and evaluation of orally active 4-(2,4-difluoro-5-(methoxycarbamoyl)phenylamino)pyrrolo[2,1-f][1,2,4]triazines as dual vascular endothelial growth factor receptor-2 and fibroblast growth factor receptor-1 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.38 | 7.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365318 | — | — | 1 | 7.07 |
| CHEMBL370266 | — | — | 1 | 6.57 |
| CHEMBL195903 | — | — | 1 | 6.38 |
| CHEMBL194498 | — | — | 1 | 6.08 |
| CHEMBL195218 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365318 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL370266 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL195903 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL194498 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL195218 | — | IC50 | = | 1500.0 | nM | 5.82 |