Assay Detail
Binding
CHEMBL828058
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Inhibitory concentration against human soluble epoxide hydrolase (sEH) at 0.24 uM
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.79 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL192549 | — | — | 1 | 7.00 |
| CHEMBL69663 | — | — | 1 | 6.96 |
| CHEMBL195796 | — | — | 1 | 6.89 |
| CHEMBL193888 | — | — | 1 | 6.80 |
| CHEMBL191767 | — | — | 1 | 6.77 |
| CHEMBL302505 | — | — | 1 | 6.77 |
| CHEMBL192293 | — | — | 1 | 6.72 |
| CHEMBL191968 | — | — | 1 | 6.64 |
| CHEMBL424822 | — | — | 1 | 6.37 |
| CHEMBL365939 | — | — | 1 | 5.86 |
| CHEMBL192843 | — | — | 1 | 5.85 |
| CHEMBL418331 | — | — | 1 | 5.69 |
| CHEMBL192470 | — | — | 1 | 5.68 |
| CHEMBL195763 | — | — | 1 | 5.62 |
| CHEMBL66498 | — | — | 1 | 5.51 |
| CHEMBL193019 | — | — | 1 | 5.40 |
| CHEMBL192461 | — | — | 1 | 5.32 |
| CHEMBL192048 | — | — | 1 | 5.30 |
| CHEMBL192273 | — | — | 1 | 5.30 |
| CHEMBL192299 | — | — | 1 | 5.23 |
| CHEMBL192523 | — | — | 1 | 5.21 |
| CHEMBL192272 | — | — | 1 | 5.03 |
| CHEMBL191355 | — | — | 1 | 4.85 |
| CHEMBL191663 | — | — | 1 | 4.80 |
| CHEMBL195748 | — | — | 1 | 4.60 |
| CHEMBL191967 | — | — | 1 | 4.42 |
| CHEMBL192136 | — | — | 1 | - |
| CHEMBL195797 | — | — | 1 | - |
| CHEMBL191982 | — | — | 1 | - |
| CHEMBL364020 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL192549 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL69663 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL195796 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL193888 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL191767 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL302505 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL192293 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL191968 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL424822 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL365939 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL192843 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL418331 | — | IC50 | = | 2060.0 | nM | 5.69 |
| CHEMBL192470 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL195763 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL66498 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL193019 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL192461 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL192048 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL192273 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL192299 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL192523 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL192272 | — | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL191355 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL191663 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL195748 | — | IC50 | = | 25200.0 | nM | 4.60 |
| CHEMBL191967 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL192136 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL195797 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL191982 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL364020 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL195542 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL192243 | — | IC50 | > | 100000.0 | nM | - |