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Assay Detail

CHEMBL828064

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of 5-hydroxytryptamine 2A receptor
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery of CC chemokine receptor-3 (CCR3) antagonists with picomolar potency.
De Lucca GV, Kim UT, Vargo BJ, Duncia JV, Santella JB, Gardner DS, Zheng C, Liauw A, Wang Z, Emmett G, Wacker DA, Welch PK, Covington M, Stowell NC, Wadman EA, Das AM, Davies P, Yeleswaram S, Graden DM, Solomon KA, Newton RC, Trainor GL, Decicco CP, Ko SS.
J Med Chem (2005) 48 : 2194 -2211
PubMed 15771462 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 3 5.80 6.04

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL250689 1 6.04
CHEMBL195433 1 5.85
CHEMBL363840 1 5.51

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL250689 IC50 = 920.0 nM 6.04
CHEMBL195433 IC50 = 1415.0 nM 5.85
CHEMBL363840 IC50 = 3120.0 nM 5.51