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Assay Detail

CHEMBL828069

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Binding
Inhibitory concentration against human cystolic isozyme II of Carbonic anhydrase
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Carbonic anhydrase 2 (CHEMBL205)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives.
Innocenti A, Antel J, Wurl M, Scozzafava A, Supuran CT.
Bioorg Med Chem Lett (2004) 14 : 5703 -5707
PubMed 15482952 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 6.05 7.10

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL7204 1 7.10
CHEMBL176495 1 7.10
CHEMBL6633 1 7.05
CHEMBL266240 1 7.02
CHEMBL186335 1 6.60
CHEMBL186636 1 6.54
CHEMBL418 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE 1 6.47
CHEMBL282157 1 6.40
CHEMBL367035 1 6.39
CHEMBL7092 1 6.25
CHEMBL574 P-TOLUENESULFONAMIDE 3.0 1 6.24
CHEMBL6724 1 6.21
CHEMBL414 CARZENIDE 2.0 1 6.06
CHEMBL268177 1 5.76
CHEMBL21 SULFANILAMIDE 4.0 1 5.62
CHEMBL6705 1 5.58
CHEMBL6784 1 5.52
CHEMBL6853 1 5.52
CHEMBL7087 1 5.51
CHEMBL363086 1 5.44
CHEMBL419 MAFENIDE 4.0 1 5.40
CHEMBL6919 1 5.24
CHEMBL148680 1 4.13
CHEMBL338802 SULFAGUANIDINE 4.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL7204 IC50 = 80.0 nM 7.10
CHEMBL176495 IC50 = 80.0 nM 7.10
CHEMBL6633 IC50 = 89.0 nM 7.05
CHEMBL266240 IC50 = 96.0 nM 7.02
CHEMBL186335 IC50 = 250.0 nM 6.60
CHEMBL186636 IC50 = 290.0 nM 6.54
CHEMBL418 2,4-DISULFAMYLTRIFLUOROMETHYLANILINE IC50 = 340.0 nM 6.47
CHEMBL282157 IC50 = 400.0 nM 6.40
CHEMBL367035 IC50 = 410.0 nM 6.39
CHEMBL7092 IC50 = 560.0 nM 6.25
CHEMBL574 P-TOLUENESULFONAMIDE IC50 = 580.0 nM 6.24
CHEMBL6724 IC50 = 620.0 nM 6.21
CHEMBL414 CARZENIDE IC50 = 880.0 nM 6.06
CHEMBL268177 IC50 = 1730.0 nM 5.76
CHEMBL21 SULFANILAMIDE IC50 = 2400.0 nM 5.62
CHEMBL6705 IC50 = 2640.0 nM 5.58
CHEMBL6784 IC50 = 3000.0 nM 5.52
CHEMBL6853 IC50 = 3000.0 nM 5.52
CHEMBL7087 IC50 = 3100.0 nM 5.51
CHEMBL363086 IC50 = 3600.0 nM 5.44
CHEMBL419 MAFENIDE IC50 = 4000.0 nM 5.40
CHEMBL6919 IC50 = 5700.0 nM 5.24
CHEMBL148680 IC50 = 73900.0 nM 4.13
CHEMBL338802 SULFAGUANIDINE IC50 > 100000.0 nM -