Assay Detail
Binding
CHEMBL828077
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro binding affinity against matrix metalloprotease 13
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-alpha converting enzyme.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 6.11 | 7.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL176467 | — | — | 1 | 7.19 |
| CHEMBL193945 | — | — | 1 | 7.02 |
| CHEMBL190215 | — | — | 1 | 6.45 |
| CHEMBL373311 | — | — | 1 | 5.40 |
| CHEMBL193316 | — | — | 1 | 5.30 |
| CHEMBL373154 | — | — | 1 | 5.30 |
| CHEMBL191076 | — | — | 1 | - |
| CHEMBL372659 | — | — | 1 | - |
| CHEMBL189591 | — | — | 1 | - |
| CHEMBL363719 | — | — | 1 | - |
| CHEMBL193084 | — | — | 1 | - |
| CHEMBL190936 | — | — | 1 | - |
| CHEMBL360193 | — | — | 1 | - |
| CHEMBL192204 | — | — | 1 | - |
| CHEMBL365167 | — | — | 1 | - |
| CHEMBL191360 | — | — | 1 | - |
| CHEMBL365386 | — | — | 1 | - |
| CHEMBL371199 | — | — | 1 | - |
| CHEMBL371781 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL176467 | — | Ki | = | 65.0 | nM | 7.19 |
| CHEMBL193945 | — | Ki | = | 95.0 | nM | 7.02 |
| CHEMBL190215 | — | Ki | = | 356.0 | nM | 6.45 |
| CHEMBL373311 | — | Ki | = | 4020.0 | nM | 5.40 |
| CHEMBL193316 | — | Ki | = | 5020.0 | nM | 5.30 |
| CHEMBL373154 | — | Ki | = | 5020.0 | nM | 5.30 |
| CHEMBL191076 | — | Ki | > | 5020.0 | nM | - |
| CHEMBL372659 | — | Ki | > | 5020.0 | nM | - |
| CHEMBL189591 | — | Ki | > | 5020.0 | nM | - |
| CHEMBL363719 | — | Ki | > | 5020.0 | nM | - |
| CHEMBL193084 | — | Ki | > | 5020.0 | nM | - |
| CHEMBL190936 | — | Ki | > | 5020.0 | nM | - |
| CHEMBL360193 | — | Ki | > | 5020.0 | nM | - |
| CHEMBL192204 | — | Ki | > | 5020.0 | nM | - |
| CHEMBL365167 | — | Ki | > | 5020.0 | nM | - |
| CHEMBL191360 | — | Ki | > | 5020.0 | nM | - |
| CHEMBL365386 | — | Ki | > | 5020.0 | nM | - |
| CHEMBL371199 | — | Ki | > | 5020.0 | nM | - |
| CHEMBL371781 | — | Ki | > | 5020.0 | nM | - |