Assay Detail
Binding
CHEMBL828086
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Concentration required for 50% inhibition of cyclin dependant kinase 2-cyclin E was measured by scintillation proximity assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 2/cyclin E1 (CHEMBL1907605) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.16 | 7.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL426972 | — | — | 1 | 7.01 |
| CHEMBL186510 | — | — | 1 | 6.58 |
| CHEMBL185498 | — | — | 1 | 6.38 |
| CHEMBL186120 | — | — | 1 | 6.01 |
| CHEMBL188172 | — | — | 1 | 5.99 |
| CHEMBL434917 | — | — | 1 | 5.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL426972 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL186510 | — | IC50 | = | 265.0 | nM | 6.58 |
| CHEMBL185498 | — | IC50 | = | 412.0 | nM | 6.38 |
| CHEMBL186120 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL188172 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL434917 | — | IC50 | = | 9770.0 | nM | 5.01 |