Assay Detail
Binding
CHEMBL828090
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Inhibitory concentration against ATPase activity of Hsp90 of Saccharomyces cerevisiae was determined by ATPase activity assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
ATP-dependent molecular chaperone HSC82 (CHEMBL4199) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.83 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL424811 | — | — | 1 | 6.96 |
| CHEMBL365617 | — | — | 1 | 6.85 |
| CHEMBL414883 | RADICICOL | — | 1 | 6.70 |
| CHEMBL190182 | — | — | 1 | 6.41 |
| CHEMBL366215 | — | — | 1 | 6.38 |
| CHEMBL191074 | — | — | 1 | 6.19 |
| CHEMBL365700 | — | — | 1 | 5.82 |
| CHEMBL371380 | — | — | 1 | 5.77 |
| CHEMBL364968 | — | — | 1 | 5.72 |
| CHEMBL426446 | — | — | 1 | 5.64 |
| CHEMBL399530 | — | — | 1 | 5.24 |
| CHEMBL109480 | TANESPIMYCIN | 3.0 | 1 | 4.87 |
| CHEMBL188965 | — | — | 1 | 4.64 |
| CHEMBL192894 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL424811 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL365617 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL414883 | RADICICOL | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL190182 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL366215 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL191074 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL365700 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL371380 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL364968 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL426446 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL399530 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL109480 | TANESPIMYCIN | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL188965 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL192894 | — | IC50 | = | 36900.0 | nM | 4.43 |