Assay Detail
Binding
CHEMBL828104
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of substance P binding to Tachykinin receptor 1 in Chinese hamster ovary cells
17
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | ovary |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Successful virtual screening for a submicromolar antagonist of the neurokinin-1 receptor based on a ligand-supported homology model.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.41 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99055 | — | — | 1 | 10.30 |
| CHEMBL356062 | — | — | 1 | 10.22 |
| CHEMBL107482 | — | — | 1 | 9.68 |
| CHEMBL28055 | — | — | 2 | 9.28 |
| CHEMBL441225 | CP-99994 | — | 1 | 9.22 |
| CHEMBL422931 | — | — | 1 | 9.00 |
| CHEMBL22194 | L-709210 | — | 1 | 8.89 |
| CHEMBL188166 | — | — | 1 | 8.80 |
| CHEMBL417784 | — | — | 1 | 8.03 |
| CHEMBL281940 | — | — | 1 | 7.97 |
| CHEMBL427514 | — | — | 1 | 7.92 |
| CHEMBL187554 | — | — | 1 | 7.17 |
| CHEMBL361031 | — | — | 1 | 6.60 |
| CHEMBL56176 | — | — | 1 | 6.40 |
| CHEMBL360815 | — | — | 1 | 5.81 |
| CHEMBL188529 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99055 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL356062 | — | IC50 | = | 0.06 | nM | 10.22 |
| CHEMBL107482 | — | IC50 | = | 0.21 | nM | 9.68 |
| CHEMBL28055 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL28055 | — | IC50 | = | 0.53 | nM | 9.28 |
| CHEMBL441225 | CP-99994 | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL422931 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL22194 | L-709210 | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL188166 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL417784 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL281940 | — | IC50 | = | 10.7 | nM | 7.97 |
| CHEMBL427514 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL187554 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL361031 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL56176 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL360815 | — | IC50 | = | 1533.0 | nM | 5.81 |
| CHEMBL188529 | — | IC50 | > | 10000.0 | nM | - |