Assay Detail
Binding
CHEMBL828112
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Displacement of [3H2]-F3-methyl AA (1) from liver X receptor-alpha in SPA assay
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 8.26 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365544 | — | — | 1 | 9.00 |
| CHEMBL555373 | — | — | 1 | 8.70 |
| CHEMBL191965 | — | — | 1 | 8.70 |
| CHEMBL23296 | — | — | 2 | 7.45 |
| CHEMBL421115 | PODOCARIC ACID | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365544 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL555373 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL191965 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL23296 | — | IC50 | = | 35.4 | nM | 7.45 |
| CHEMBL23296 | — | IC50 | = | 35.4 | nM | 7.45 |
| CHEMBL421115 | PODOCARIC ACID | IC50 | > | 50000.0 | nM | - |