Assay Detail
Binding
CHEMBL828125
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Ability to displace [3H]spiperone from human Dopamine receptor D4.2 stably transfected in human embryonic kidney 298 cells
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
N-(1-Benzylpyrrolidin-3-yl)arylbenzamides as potent and selective human dopamine D4 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 19 | 8.14 | 8.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL361035 | — | — | 1 | 8.82 |
| CHEMBL426062 | — | — | 1 | 8.70 |
| CHEMBL187122 | — | — | 1 | 8.70 |
| CHEMBL364782 | — | — | 1 | 8.70 |
| CHEMBL185156 | — | — | 1 | 8.52 |
| CHEMBL187236 | — | — | 1 | 8.52 |
| CHEMBL360424 | — | — | 1 | 8.52 |
| CHEMBL187113 | — | — | 1 | 8.47 |
| CHEMBL360394 | — | — | 1 | 8.40 |
| CHEMBL366043 | — | — | 1 | 8.30 |
| CHEMBL184388 | — | — | 1 | 8.10 |
| CHEMBL187804 | — | — | 1 | 7.77 |
| CHEMBL182075 | — | — | 1 | 7.77 |
| CHEMBL183160 | — | — | 1 | 7.77 |
| CHEMBL366304 | — | — | 1 | 7.75 |
| CHEMBL424808 | — | — | 1 | 7.62 |
| CHEMBL186558 | — | — | 1 | 7.62 |
| CHEMBL184551 | — | — | 1 | 7.44 |
| CHEMBL427522 | — | — | 1 | 7.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL361035 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL426062 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL187122 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL364782 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL185156 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL187236 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL360424 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL187113 | — | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL360394 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL366043 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL184388 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL187804 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL182075 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL183160 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL366304 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL424808 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL186558 | — | Ki | = | 24.0 | nM | 7.62 |
| CHEMBL184551 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL427522 | — | Ki | = | 70.0 | nM | 7.16 |