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Assay Detail

CHEMBL828131

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Effective concentration for human Vasopressin V2 receptor
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Expert

Target

Vasopressin V2 receptor (CHEMBL1790)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Non-peptide oxytocin agonists.
Pitt GR, Batt AR, Haigh RM, Penson AM, Robson PA, Rooker DP, Tartar AL, Trim JE, Yea CM, Roe MB.
Bioorg Med Chem Lett (2004) 14 : 4585 -4589
PubMed 15357997 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 11 6.18 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL181487 1 7.00
CHEMBL182627 1 6.70
CHEMBL362483 1 6.64
CHEMBL445393 1 6.24
CHEMBL360648 1 6.07
CHEMBL365862 1 6.05
CHEMBL362382 1 5.96
CHEMBL443300 1 5.92
CHEMBL364994 1 5.89
CHEMBL184696 1 5.75
CHEMBL185152 1 5.75

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL181487 EC50 = 100.0 nM 7.00
CHEMBL182627 EC50 = 200.0 nM 6.70
CHEMBL362483 EC50 = 230.0 nM 6.64
CHEMBL445393 EC50 = 570.0 nM 6.24
CHEMBL360648 EC50 = 850.0 nM 6.07
CHEMBL365862 EC50 = 890.0 nM 6.05
CHEMBL362382 EC50 = 1100.0 nM 5.96
CHEMBL443300 EC50 = 1200.0 nM 5.92
CHEMBL364994 EC50 = 1300.0 nM 5.89
CHEMBL184696 EC50 = 1800.0 nM 5.75
CHEMBL185152 EC50 = 1800.0 nM 5.75