Assay Detail
Binding
CHEMBL828133
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to stimulate SHP-1 enzymatic activity by 50%
15
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 6 (CHEMBL3166) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and biological evaluation of linear and cyclic phosphopeptide ligands of the N-terminal SH2 domain of protein tyrosine phosphatase SHP-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 4.18 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL274087 | — | — | 1 | 4.30 |
| CHEMBL413215 | — | — | 2 | 4.30 |
| CHEMBL2371862 | — | — | 1 | 4.22 |
| CHEMBL273780 | — | — | 1 | 4.16 |
| CHEMBL2371864 | — | — | 1 | 4.12 |
| CHEMBL412186 | — | — | 1 | 4.10 |
| CHEMBL413492 | — | — | 1 | 4.07 |
| CHEMBL269042 | — | — | 1 | - |
| CHEMBL408337 | — | — | 1 | - |
| CHEMBL371014 | — | — | 1 | - |
| CHEMBL386749 | — | — | 1 | - |
| CHEMBL2371863 | — | — | 1 | - |
| CHEMBL412918 | — | — | 1 | - |
| CHEMBL386769 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL274087 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL413215 | — | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL2371862 | — | EC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL273780 | — | EC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL2371864 | — | EC50 | = | 75000.0 | nM | 4.12 |
| CHEMBL412186 | — | EC50 | = | 80000.0 | nM | 4.10 |
| CHEMBL413492 | — | EC50 | = | 85000.0 | nM | 4.07 |
| CHEMBL269042 | — | EC50 | = | 150000.0 | nM | - |
| CHEMBL408337 | — | EC50 | - | nM | - | |
| CHEMBL371014 | — | EC50 | = | 160000.0 | nM | - |
| CHEMBL386749 | — | EC50 | = | 140000.0 | nM | - |
| CHEMBL2371863 | — | EC50 | = | 140000.0 | nM | - |
| CHEMBL413215 | — | EC50 | = | 220000.0 | nM | - |
| CHEMBL412918 | — | EC50 | = | 180000.0 | nM | - |
| CHEMBL386769 | — | EC50 | = | 220000.0 | nM | - |