Assay Detail
Binding
CHEMBL828154
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Inhibitory concentration against purified poly ADP-ribose polymerase-1 done in PARP inhibition assay kit
25
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery of potent poly(ADP-ribose) polymerase-1 inhibitors from the modification of indeno[1,2-c]isoquinolinone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.63 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190434 | — | — | 1 | 9.00 |
| CHEMBL365086 | — | — | 1 | 8.00 |
| CHEMBL371339 | — | — | 1 | 7.10 |
| CHEMBL194155 | — | — | 1 | 7.01 |
| CHEMBL371819 | — | — | 1 | 7.00 |
| CHEMBL191185 | — | — | 1 | 6.98 |
| CHEMBL364752 | — | — | 1 | 6.97 |
| CHEMBL371596 | — | — | 1 | 6.96 |
| CHEMBL187834 | — | — | 1 | 6.52 |
| CHEMBL363363 | — | — | 1 | 6.52 |
| CHEMBL364691 | — | — | 1 | 6.41 |
| CHEMBL192951 | — | — | 2 | 6.40 |
| CHEMBL189695 | — | — | 1 | 6.35 |
| CHEMBL370673 | — | — | 1 | 6.30 |
| CHEMBL433965 | — | — | 1 | 6.30 |
| CHEMBL370045 | — | — | 1 | 6.30 |
| CHEMBL190895 | — | — | 1 | 6.19 |
| CHEMBL372717 | — | — | 1 | 6.16 |
| CHEMBL191469 | — | — | 1 | 6.10 |
| CHEMBL426270 | — | — | 1 | 6.10 |
| CHEMBL81977 | 3-AMINOBENZAMIDE | — | 1 | 4.52 |
| CHEMBL363380 | — | — | 1 | - |
| CHEMBL365390 | — | — | 1 | - |
| CHEMBL361500 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190434 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL365086 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL371339 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL194155 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL371819 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL191185 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL364752 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL371596 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL187834 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL363363 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL364691 | — | IC50 | = | 394.0 | nM | 6.41 |
| CHEMBL192951 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL189695 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL370673 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL433965 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL370045 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL190895 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL372717 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL191469 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL426270 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL81977 | 3-AMINOBENZAMIDE | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL363380 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL192951 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL365390 | — | IC50 | > | 3000.0 | nM | - |
| CHEMBL361500 | — | IC50 | > | 3000.0 | nM | - |