Assay Detail
Binding
CHEMBL828244
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human transient receptor potential vanilloid 1 receptor (n=5)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Transient receptor potential cation channel subfamily V member 1 (CHEMBL4794) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.66 | 7.13 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL391997 | CAPSAZEPINE | — | 1 | 7.13 |
| CHEMBL3138733 | — | — | 1 | 6.58 |
| CHEMBL367039 | — | — | 1 | 6.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL391997 | CAPSAZEPINE | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL3138733 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL367039 | — | IC50 | = | 526.0 | nM | 6.28 |