Assay Detail
Binding
CHEMBL828249
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Inhibitory concentration against human 5-hydroxytryptamine 6 receptor transfected in HeLa cells in cAMP assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HeLa |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-indoles as novel 5-HT6 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.88 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL185850 | — | — | 1 | 7.64 |
| CHEMBL185958 | — | — | 1 | 7.33 |
| CHEMBL184652 | — | — | 1 | 6.45 |
| CHEMBL425714 | — | — | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL185850 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL185958 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL184652 | — | IC50 | = | 359.0 | nM | 6.45 |
| CHEMBL425714 | — | IC50 | = | 792.0 | nM | 6.10 |