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Assay Detail

CHEMBL828251

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity for Dopamine transporter
21
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Benzothienyloxy phenylpropanamines, novel dual inhibitors of serotonin and norepinephrine reuptake.
Boot JR, Brace G, Delatour CL, Dezutter N, Fairhurst J, Findlay J, Gallagher PT, Hoes I, Mahadevan S, Mitchell SN, Rathmell RE, Richards SJ, Simmonds RG, Wallace L, Whatton MA.
Bioorg Med Chem Lett (2004) 14 : 5395 -5399
PubMed 15454233 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 21 6.61 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL362520 2 7.00
CHEMBL186785 2 6.94
CHEMBL426251 1 6.92
CHEMBL361407 2 6.79
CHEMBL365253 2 6.75
CHEMBL364776 1 6.72
CHEMBL427154 1 6.68
CHEMBL435695 1 6.66
CHEMBL1175 DULOXETINE 4.0 1 6.62
CHEMBL363465 1 6.58
CHEMBL184210 1 6.58
CHEMBL361710 1 6.57
CHEMBL361304 1 6.36
CHEMBL181542 1 6.32
CHEMBL435504 1 6.27
CHEMBL186503 1 6.03
CHEMBL363987 1 5.85

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL362520 Ki = 100.0 nM 7.00
CHEMBL186785 Ki = 114.0 nM 6.94
CHEMBL426251 Ki = 120.0 nM 6.92
CHEMBL362520 Ki = 134.0 nM 6.87
CHEMBL186785 Ki = 147.0 nM 6.83
CHEMBL361407 Ki = 164.0 nM 6.79
CHEMBL361407 Ki = 176.0 nM 6.75
CHEMBL365253 Ki = 177.0 nM 6.75
CHEMBL364776 Ki = 190.0 nM 6.72
CHEMBL365253 Ki = 196.0 nM 6.71
CHEMBL427154 Ki = 208.0 nM 6.68
CHEMBL435695 Ki = 220.0 nM 6.66
CHEMBL1175 DULOXETINE Ki = 240.0 nM 6.62
CHEMBL184210 Ki = 260.0 nM 6.58
CHEMBL363465 Ki = 260.0 nM 6.58
CHEMBL361710 Ki = 270.0 nM 6.57
CHEMBL361304 Ki = 440.0 nM 6.36
CHEMBL181542 Ki = 480.0 nM 6.32
CHEMBL435504 Ki = 540.0 nM 6.27
CHEMBL186503 Ki = 930.0 nM 6.03
CHEMBL363987 Ki = 1400.0 nM 5.85