Assay Detail
Binding
CHEMBL828333
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MTAP as equilibrium dissociation constant
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
S-methyl-5'-thioadenosine phosphorylase (CHEMBL4941) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 16 | 9.47 | 11.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365813 | — | — | 1 | 11.00 |
| CHEMBL191544 | — | — | 1 | 10.47 |
| CHEMBL188375 | — | — | 1 | 10.05 |
| CHEMBL365378 | — | — | 1 | 9.96 |
| CHEMBL425188 | — | — | 1 | 9.92 |
| CHEMBL190216 | — | — | 1 | 9.80 |
| CHEMBL190139 | — | — | 1 | 9.80 |
| CHEMBL188034 | — | — | 1 | 9.77 |
| CHEMBL191281 | — | — | 1 | 9.59 |
| CHEMBL191177 | — | — | 1 | 9.57 |
| CHEMBL190867 | — | — | 1 | 9.43 |
| CHEMBL191436 | — | — | 1 | 9.15 |
| CHEMBL1161749 | — | — | 1 | 9.00 |
| CHEMBL189911 | — | — | 1 | 8.52 |
| CHEMBL189837 | — | — | 1 | 8.10 |
| CHEMBL189910 | — | — | 1 | 7.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365813 | — | Ki | = | 0.01 | nM | 11.00 |
| CHEMBL191544 | — | Ki | = | 0.034 | nM | 10.47 |
| CHEMBL188375 | — | Ki | = | 0.09 | nM | 10.05 |
| CHEMBL365378 | — | Ki | = | 0.11 | nM | 9.96 |
| CHEMBL425188 | — | Ki | = | 0.12 | nM | 9.92 |
| CHEMBL190216 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL190139 | — | Ki | = | 0.16 | nM | 9.80 |
| CHEMBL188034 | — | Ki | = | 0.17 | nM | 9.77 |
| CHEMBL191281 | — | Ki | = | 0.26 | nM | 9.59 |
| CHEMBL191177 | — | Ki | = | 0.27 | nM | 9.57 |
| CHEMBL190867 | — | Ki | = | 0.37 | nM | 9.43 |
| CHEMBL191436 | — | Ki | = | 0.7 | nM | 9.15 |
| CHEMBL1161749 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL189911 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL189837 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL189910 | — | Ki | = | 42.0 | nM | 7.38 |