Assay Detail
Binding
CHEMBL828343
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against human metabotropic glutamate receptor 1 transmembrane domain
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.50 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL175643 | — | — | 1 | 7.70 |
| CHEMBL177962 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL175643 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL177962 | — | IC50 | = | 5000.0 | nM | 5.30 |