Assay Detail
Binding
CHEMBL828346
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Inhibition of fibrinogen binding to alphaV-beta3 integrin receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Ligand binding analysis for human alpha5beta1 integrin: strategies for designing new alpha5beta1 integrin antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.21 | 7.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339751 | — | — | 1 | 7.50 |
| CHEMBL435806 | — | — | 1 | 7.47 |
| CHEMBL338806 | — | — | 1 | 7.39 |
| CHEMBL338439 | — | — | 1 | 7.31 |
| CHEMBL340309 | — | — | 1 | 7.24 |
| CHEMBL364063 | — | — | 1 | 7.24 |
| CHEMBL126071 | — | — | 1 | 7.06 |
| CHEMBL126983 | — | — | 1 | 6.89 |
| CHEMBL126416 | — | — | 1 | 6.75 |
| CHEMBL2096812 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339751 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL435806 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL338806 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL338439 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL340309 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL364063 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL126071 | — | IC50 | = | 87.0 | nM | 7.06 |
| CHEMBL126983 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL126416 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL2096812 | — | IC50 | > | 1000.0 | nM | - |