Assay Detail
Binding
CHEMBL828348
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of 2(S)-(4-125I-benzenesulphonylamino)-3-4-[2-(5,6,7,8-tetrahydro- [1,8]naphthyridin-2-yl)-ethyl]-benzoylamino-propionic acid binding to alphaV-beta3 integrin
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Nonpeptide alpha(v)beta3 antagonists: identification of potent, chain-shortened 7-oxo RGD mimetics.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 9.56 | 9.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181366 | — | — | 1 | 9.80 |
| CHEMBL179069 | — | — | 1 | 9.62 |
| CHEMBL369530 | — | — | 1 | 9.62 |
| CHEMBL180489 | — | — | 1 | 9.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181366 | — | IC50 | = | 0.16 | nM | 9.80 |
| CHEMBL179069 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL369530 | — | IC50 | = | 0.24 | nM | 9.62 |
| CHEMBL180489 | — | IC50 | = | 0.65 | nM | 9.19 |