Assay Detail
Binding
CHEMBL828388
Review assay metadata, readout intent, target linkage, and publication context from the same page.
inhibitory concentration against RNA dependent RNA polymerase Nonstructural protein 5B of hepatitis C virus
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepacivirus hominis |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
RNA-directed RNA polymerase (CHEMBL4296320) ↗| Type | SINGLE PROTEIN |
| Organism | Hepacivirus hominis |
Publication
Active site inhibitors of HCV NS5B polymerase. The development and pharmacophore of 2-thienyl-5,6-dihydroxypyrimidine-4-carboxylic acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 4.93 | 5.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL181653 | — | — | 1 | 5.58 |
| CHEMBL366051 | — | — | 1 | 5.38 |
| CHEMBL16326 | — | — | 1 | 5.24 |
| CHEMBL185589 | — | — | 1 | 5.21 |
| CHEMBL440562 | — | — | 1 | 4.52 |
| CHEMBL181491 | — | — | 1 | 4.31 |
| CHEMBL183018 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL181653 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL366051 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL16326 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL185589 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL440562 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL181491 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL183018 | — | IC50 | = | 50000.0 | nM | 4.30 |