Assay Detail
Functional
CHEMBL828392
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]leucine uptake into CHO cells by L-amino acid transporters
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cricetulus griseus |
| Cell Type | CHO |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Structure-activity relationships of pregabalin and analogues that target the alpha(2)-delta protein.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 4.34 | 4.55 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL365562 | — | — | 1 | 4.55 |
| CHEMBL940 | GABAPENTIN | 4.0 | 1 | 4.52 |
| CHEMBL190656 | — | — | 1 | 4.22 |
| CHEMBL435129 | — | — | 1 | 4.05 |
| CHEMBL1059 | PREGABALIN | 4.0 | 1 | - |
| CHEMBL167003 | — | — | 1 | - |
| CHEMBL190074 | — | — | 1 | - |
| CHEMBL363579 | — | — | 1 | - |
| CHEMBL363611 | — | — | 1 | - |
| CHEMBL193353 | — | — | 1 | - |
| CHEMBL364743 | — | — | 1 | - |
| CHEMBL192532 | — | — | 1 | - |
| CHEMBL365160 | — | — | 1 | - |
| CHEMBL363005 | — | — | 1 | - |
| CHEMBL190602 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL365562 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL940 | GABAPENTIN | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL190656 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL435129 | — | IC50 | = | 89000.0 | nM | 4.05 |
| CHEMBL1059 | PREGABALIN | IC50 | = | 158000.0 | nM | - |
| CHEMBL167003 | — | IC50 | = | 355000.0 | nM | - |
| CHEMBL190074 | — | IC50 | = | 142000.0 | nM | - |
| CHEMBL363579 | — | IC50 | = | 146000.0 | nM | - |
| CHEMBL363611 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL193353 | — | IC50 | = | 117000.0 | nM | - |
| CHEMBL364743 | — | IC50 | > | 100000000.0 | nM | - |
| CHEMBL192532 | — | IC50 | > | 8300000.0 | nM | - |
| CHEMBL365160 | — | IC50 | > | 8300000.0 | nM | - |
| CHEMBL363005 | — | IC50 | > | 10000000.0 | nM | - |
| CHEMBL190602 | — | IC50 | = | 157000.0 | nM | - |