Assay Detail
Binding
CHEMBL828426
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Inhibitory concentration against Plasmodium falciparum glutathione reductase
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Plasmodium falciparum |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
5-substituted tetrazoles as bioisosteres of carboxylic acids. Bioisosterism and mechanistic studies on glutathione reductase inhibitors as antimalarials.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.94 | 5.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL135287 | — | — | 1 | 5.35 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | 4.0 | 1 | 5.19 |
| CHEMBL187788 | — | — | 1 | 4.97 |
| CHEMBL190592 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL135287 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL405110 | METHYLENE BLUE ANHYDROUS | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL187788 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL190592 | — | IC50 | = | 57000.0 | nM | 4.24 |