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Assay Detail

CHEMBL828487

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Binding
Inhibitory concentration against histone deacetylase of HeLa cells
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type HeLa
Confidence 5 — Multiple protein complex / RNA
Curated By Autocuration

Target

Histone deacetylase (CHEMBL2093865)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Identification of a potent non-hydroxamate histone deacetylase inhibitor by mechanism-based drug design.
Suzuki T, Matsuura A, Kouketsu A, Nakagawa H, Miyata N.
Bioorg Med Chem Lett (2005) 15 : 331 -335
PubMed 15603949 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 5.45 6.55

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL98 VORINOSTAT 4.0 1 6.55
CHEMBL178727 1 6.41
CHEMBL180406 1 5.52
CHEMBL183748 1 4.96
CHEMBL178150 1 4.66
CHEMBL369343 1 4.62
CHEMBL178542 1 -
CHEMBL426420 1 -
CHEMBL362408 1 -
CHEMBL178726 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL98 VORINOSTAT IC50 = 280.0 nM 6.55
CHEMBL178727 IC50 = 390.0 nM 6.41
CHEMBL180406 IC50 = 3000.0 nM 5.52
CHEMBL183748 IC50 = 11000.0 nM 4.96
CHEMBL178150 IC50 = 22000.0 nM 4.66
CHEMBL369343 IC50 = 24000.0 nM 4.62
CHEMBL178542 IC50 = 7500000.0 nM -
CHEMBL426420 IC50 = 230000.0 nM -
CHEMBL362408 IC50 > 100000.0 nM -
CHEMBL178726 IC50 > 100000.0 nM -