Assay Detail
Binding
CHEMBL828527
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Inhibitory concentration against MMP-13
24
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of 3-OH-3-methylpipecolic hydroxamates: potent orally active inhibitors of aggrecanase and MMP-13.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 8.59 | 9.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL187474 | — | — | 1 | 9.37 |
| CHEMBL182306 | — | — | 1 | 9.31 |
| CHEMBL186663 | — | — | 1 | 9.19 |
| CHEMBL360854 | — | — | 1 | 9.06 |
| CHEMBL187092 | — | — | 1 | 9.05 |
| CHEMBL183474 | — | — | 1 | 9.00 |
| CHEMBL369115 | — | — | 1 | 8.82 |
| CHEMBL186743 | — | — | 1 | 8.82 |
| CHEMBL365658 | — | — | 1 | 8.80 |
| CHEMBL365247 | — | — | 1 | 8.70 |
| CHEMBL187245 | — | — | 1 | 8.60 |
| CHEMBL186500 | — | — | 1 | 8.60 |
| CHEMBL365283 | — | — | 1 | 8.54 |
| CHEMBL363126 | — | — | 1 | 8.49 |
| CHEMBL435102 | — | — | 1 | 8.44 |
| CHEMBL183995 | — | — | 2 | 8.43 |
| CHEMBL446697 | — | — | 1 | 8.39 |
| CHEMBL364643 | — | — | 1 | 8.31 |
| CHEMBL185168 | — | — | 1 | 8.19 |
| CHEMBL187141 | — | — | 1 | 8.13 |
| CHEMBL426975 | — | — | 1 | 8.01 |
| CHEMBL187852 | — | — | 1 | 7.75 |
| CHEMBL436277 | — | — | 1 | 7.75 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL187474 | — | IC50 | = | 0.43 | nM | 9.37 |
| CHEMBL182306 | — | IC50 | = | 0.49 | nM | 9.31 |
| CHEMBL186663 | — | IC50 | = | 0.65 | nM | 9.19 |
| CHEMBL360854 | — | IC50 | = | 0.87 | nM | 9.06 |
| CHEMBL187092 | — | IC50 | = | 0.9 | nM | 9.05 |
| CHEMBL183474 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL369115 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL186743 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL365658 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL365247 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL186500 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL187245 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL365283 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL363126 | — | IC50 | = | 3.2 | nM | 8.49 |
| CHEMBL435102 | — | IC50 | = | 3.6 | nM | 8.44 |
| CHEMBL183995 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL183995 | — | IC50 | = | 3.7 | nM | 8.43 |
| CHEMBL446697 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL364643 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL185168 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL187141 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL426975 | — | IC50 | = | 9.7 | nM | 8.01 |
| CHEMBL187852 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL436277 | — | IC50 | = | 18.0 | nM | 7.75 |