Assay Detail
Binding
CHEMBL828555
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of vascular endothelial growth factor receptor 2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Vascular endothelial growth factor receptor 2 (CHEMBL279) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.56 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190805 | — | — | 1 | 5.97 |
| CHEMBL365937 | — | — | 1 | 5.70 |
| CHEMBL191336 | — | — | 1 | 5.46 |
| CHEMBL363590 | — | — | 1 | 5.38 |
| CHEMBL191377 | — | — | 1 | 5.30 |
| CHEMBL193029 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190805 | — | IC50 | = | 1067.0 | nM | 5.97 |
| CHEMBL365937 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL191336 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL363590 | — | IC50 | = | 4140.0 | nM | 5.38 |
| CHEMBL191377 | — | IC50 | = | 5030.0 | nM | 5.30 |
| CHEMBL193029 | — | IC50 | > | 10000.0 | nM | - |