Assay Detail
Binding
CHEMBL828575
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Inhibitory concentration against recombinant human Protein kinase C beta 1
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.23 | 8.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL91829 | RUBOXISTAURIN | 3.0 | 1 | 8.33 |
| CHEMBL366266 | — | — | 1 | 7.68 |
| CHEMBL266487 | RO-316233 | — | 1 | 6.52 |
| CHEMBL183310 | — | — | 1 | 6.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL91829 | RUBOXISTAURIN | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL366266 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL266487 | RO-316233 | IC50 | = | 304.0 | nM | 6.52 |
| CHEMBL183310 | — | IC50 | = | 395.0 | nM | 6.40 |