Assay Detail
Binding
CHEMBL828581
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of VLA-4 receptor of Jurkat cells in BURJ assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Jurkat |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Influence of acid surrogates toward potency of VLA-4 antagonist.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.99 | 10.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296804 | — | — | 1 | 10.52 |
| CHEMBL373343 | — | — | 1 | 8.22 |
| CHEMBL263565 | — | — | 1 | 8.00 |
| CHEMBL190640 | — | — | 1 | 7.96 |
| CHEMBL365145 | — | — | 1 | 7.92 |
| CHEMBL366117 | — | — | 1 | 7.89 |
| CHEMBL366338 | — | — | 1 | 7.70 |
| CHEMBL190761 | — | — | 1 | 7.22 |
| CHEMBL370943 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296804 | — | IC50 | = | 0.03 | nM | 10.52 |
| CHEMBL373343 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL263565 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL190640 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL365145 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL366117 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL366338 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL190761 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL370943 | — | IC50 | = | 300.0 | nM | 6.52 |