Assay Detail
Binding
CHEMBL828585
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Inhibition of human Peroxisome proliferator activated receptor gamma binding
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor gamma (CHEMBL235) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of a novel series of peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes and dyslipidemia.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.03 | 6.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | 4.0 | 1 | 6.60 |
| CHEMBL190665 | — | — | 1 | 5.91 |
| CHEMBL192152 | — | — | 1 | 5.80 |
| CHEMBL190739 | — | — | 1 | 5.79 |
| CHEMBL363369 | — | — | 1 | - |
| CHEMBL190645 | — | — | 1 | - |
| CHEMBL364774 | — | — | 1 | - |
| CHEMBL190352 | — | — | 1 | - |
| CHEMBL981 | FENOFIBRIC ACID | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121 | ROSIGLITAZONE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL190665 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL192152 | — | IC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL190739 | — | IC50 | = | 1620.0 | nM | 5.79 |
| CHEMBL363369 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL190645 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL364774 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL190352 | — | IC50 | > | 15000.0 | nM | - |
| CHEMBL981 | FENOFIBRIC ACID | IC50 | > | 50000.0 | nM | - |