Assay Detail
Binding
CHEMBL828599
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Inhibitory concentration against Mycobacterium avium DHFR
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mycobacterium avium |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and antifolate activity of new analogues of piritrexim and other diaminopyrimidine dihydrofolate reductase inhibitors with omega-carboxyalkoxy or omega-carboxy-1-alkynyl substitution in the side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 8.76 | 10.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL190650 | — | — | 1 | 10.24 |
| CHEMBL189952 | — | — | 1 | 9.59 |
| CHEMBL190199 | — | — | 1 | 9.54 |
| CHEMBL190486 | — | — | 1 | 9.49 |
| CHEMBL188540 | — | — | 1 | 9.46 |
| CHEMBL191071 | — | — | 1 | 9.33 |
| CHEMBL370239 | — | — | 1 | 9.24 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 9.21 |
| CHEMBL192835 | — | — | 1 | 9.16 |
| CHEMBL187570 | — | — | 1 | 9.04 |
| CHEMBL425893 | — | — | 1 | 9.00 |
| CHEMBL187595 | — | — | 1 | 8.89 |
| CHEMBL190026 | — | — | 1 | 8.74 |
| CHEMBL189796 | — | — | 1 | 8.74 |
| CHEMBL300419 | — | — | 1 | 8.62 |
| CHEMBL189369 | — | — | 1 | 8.54 |
| CHEMBL190935 | — | — | 1 | 8.25 |
| CHEMBL189012 | — | — | 1 | 8.20 |
| CHEMBL190340 | — | — | 1 | 8.07 |
| CHEMBL189953 | — | — | 1 | 8.03 |
| CHEMBL435938 | — | — | 1 | 7.92 |
| CHEMBL190807 | — | — | 1 | 7.77 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL190650 | — | IC50 | = | 0.057 | nM | 10.24 |
| CHEMBL189952 | — | IC50 | = | 0.26 | nM | 9.59 |
| CHEMBL190199 | — | IC50 | = | 0.29 | nM | 9.54 |
| CHEMBL190486 | — | IC50 | = | 0.32 | nM | 9.49 |
| CHEMBL188540 | — | IC50 | = | 0.35 | nM | 9.46 |
| CHEMBL191071 | — | IC50 | = | 0.47 | nM | 9.33 |
| CHEMBL370239 | — | IC50 | = | 0.57 | nM | 9.24 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 0.61 | nM | 9.21 |
| CHEMBL192835 | — | IC50 | = | 0.69 | nM | 9.16 |
| CHEMBL187570 | — | IC50 | = | 0.92 | nM | 9.04 |
| CHEMBL425893 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL187595 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL190026 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL189796 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL300419 | — | IC50 | = | 2.4 | nM | 8.62 |
| CHEMBL189369 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL190935 | — | IC50 | = | 5.6 | nM | 8.25 |
| CHEMBL189012 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL190340 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL189953 | — | IC50 | = | 9.4 | nM | 8.03 |
| CHEMBL435938 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL190807 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 300.0 | nM | 6.52 |