Assay Detail
Binding
CHEMBL828603
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against ScMetAP1 enzyme activity
36
Total Activities
36
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Saccharomyces cerevisiae |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Methionine aminopeptidase 1 (CHEMBL2526) ↗| Type | SINGLE PROTEIN |
| Organism | Saccharomyces cerevisiae S288c |
Publication
Identification of potent type I MetAPs inhibitors by simple bioisosteric replacement. Part 2: SAR studies of 5-heteroalkyl substituted TCAT derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 36 | 6.01 | 7.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188263 | — | — | 1 | 7.12 |
| CHEMBL363943 | — | — | 1 | 6.82 |
| CHEMBL426802 | — | — | 1 | 6.64 |
| CHEMBL189688 | — | — | 1 | 6.57 |
| CHEMBL188976 | — | — | 1 | 6.51 |
| CHEMBL363299 | — | — | 1 | 6.47 |
| CHEMBL188845 | — | — | 1 | 6.46 |
| CHEMBL441389 | — | — | 1 | 6.41 |
| CHEMBL190357 | — | — | 1 | 6.40 |
| CHEMBL188429 | — | — | 1 | 6.39 |
| CHEMBL365192 | — | — | 1 | 6.36 |
| CHEMBL361480 | — | — | 1 | 6.35 |
| CHEMBL189619 | — | — | 1 | 6.35 |
| CHEMBL186028 | — | — | 1 | 6.35 |
| CHEMBL364821 | — | — | 1 | 6.30 |
| CHEMBL179919 | — | — | 1 | 6.30 |
| CHEMBL361307 | — | — | 1 | 6.28 |
| CHEMBL189127 | — | — | 1 | 6.26 |
| CHEMBL371393 | — | — | 1 | 6.24 |
| CHEMBL362123 | — | — | 1 | 6.24 |
| CHEMBL190342 | — | — | 1 | 6.12 |
| CHEMBL363875 | — | — | 1 | 6.10 |
| CHEMBL178091 | — | — | 1 | 6.06 |
| CHEMBL362937 | — | — | 1 | 5.81 |
| CHEMBL188053 | — | — | 1 | 5.75 |
| CHEMBL175540 | — | — | 1 | 5.65 |
| CHEMBL188575 | — | — | 1 | 5.51 |
| CHEMBL188195 | — | — | 1 | 5.49 |
| CHEMBL188796 | — | — | 1 | 5.43 |
| CHEMBL190195 | — | — | 1 | 5.37 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188263 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL363943 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL426802 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL189688 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL188976 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL363299 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL188845 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL441389 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL190357 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL188429 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL365192 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL361480 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL189619 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL186028 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL179919 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL364821 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL361307 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL189127 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL371393 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL362123 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL190342 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL363875 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL178091 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL362937 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL188053 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL175540 | — | IC50 | = | 2260.0 | nM | 5.65 |
| CHEMBL188575 | — | IC50 | = | 3080.0 | nM | 5.51 |
| CHEMBL188195 | — | IC50 | = | 3210.0 | nM | 5.49 |
| CHEMBL188796 | — | IC50 | = | 3720.0 | nM | 5.43 |
| CHEMBL190195 | — | IC50 | = | 4250.0 | nM | 5.37 |
| CHEMBL366071 | — | IC50 | = | 6040.0 | nM | 5.22 |
| CHEMBL365566 | — | IC50 | = | 6430.0 | nM | 5.19 |
| CHEMBL89671 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL365124 | — | IC50 | = | 7530.0 | nM | 5.12 |
| CHEMBL365225 | — | IC50 | = | 10390.0 | nM | 4.98 |
| CHEMBL188759 | — | IC50 | = | 17920.0 | nM | 4.75 |