Assay Detail
Binding
CHEMBL828606
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration tested against Cyclin dependant kinase 1-cyclinB
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 1/cyclin B1 (CHEMBL1907602) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Novel CDK inhibition profiles of structurally varied 1-aza-9-oxafluorenes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 4.57 | 5.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL133712 | — | — | 1 | 5.38 |
| CHEMBL183408 | — | — | 1 | 4.19 |
| CHEMBL361573 | — | — | 1 | 4.15 |
| CHEMBL179219 | — | — | 1 | - |
| CHEMBL361537 | — | — | 1 | - |
| CHEMBL361565 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL133712 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL183408 | — | IC50 | = | 64300.0 | nM | 4.19 |
| CHEMBL361573 | — | IC50 | = | 70700.0 | nM | 4.15 |
| CHEMBL179219 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL361537 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL361565 | — | IC50 | > | 100000.0 | nM | - |