Assay Detail
Binding
CHEMBL828662
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Toxoplasma gondii dihydrofolate reductase
177
Total Activities
172
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
CoMFA and CoMSIA analyses of Pneumocystis carinii dihydrofolate reductase, Toxoplasma gondii dihydrofolate reductase, and rat liver dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 177 | 7.00 | 9.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50514 | — | — | 1 | 9.24 |
| CHEMBL55063 | — | — | 1 | 9.08 |
| CHEMBL310880 | — | — | 2 | 8.77 |
| CHEMBL52433 | — | — | 1 | 8.57 |
| CHEMBL23569 | — | — | 1 | 8.32 |
| CHEMBL32113 | — | — | 1 | 8.20 |
| CHEMBL179319 | — | — | 1 | 8.20 |
| CHEMBL53693 | — | — | 1 | 8.17 |
| CHEMBL123122 | — | — | 1 | 8.15 |
| CHEMBL81119 | — | — | 1 | 8.15 |
| CHEMBL264386 | — | — | 1 | 8.14 |
| CHEMBL23532 | — | — | 1 | 8.13 |
| CHEMBL84457 | — | — | 2 | 8.13 |
| CHEMBL49454 | — | — | 1 | 8.11 |
| CHEMBL283518 | — | — | 1 | 8.06 |
| CHEMBL142741 | — | — | 1 | 8.05 |
| CHEMBL113816 | — | — | 1 | 8.03 |
| CHEMBL80065 | — | — | 1 | 8.02 |
| CHEMBL57624 | — | — | 1 | 8.01 |
| CHEMBL333791 | — | — | 1 | 8.00 |
| CHEMBL80066 | — | — | 1 | 7.96 |
| CHEMBL420224 | — | — | 1 | 7.92 |
| CHEMBL120821 | — | — | 1 | 7.92 |
| CHEMBL312348 | — | — | 1 | 7.92 |
| CHEMBL115788 | — | — | 1 | 7.89 |
| CHEMBL299174 | — | — | 1 | 7.85 |
| CHEMBL32190 | — | — | 1 | 7.85 |
| CHEMBL23867 | — | — | 1 | 7.84 |
| CHEMBL121868 | — | — | 1 | 7.82 |
| CHEMBL54792 | — | — | 1 | 7.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50514 | — | IC50 | = | 0.58 | nM | 9.24 |
| CHEMBL55063 | — | IC50 | = | 0.84 | nM | 9.08 |
| CHEMBL310880 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL52433 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL23569 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL310880 | — | IC50 | = | 5.4 | nM | 8.27 |
| CHEMBL179319 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL32113 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL53693 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL81119 | — | IC50 | = | 7.1 | nM | 8.15 |
| CHEMBL123122 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL264386 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL84457 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL23532 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL49454 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL283518 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL142741 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL113816 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL80065 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL57624 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL333791 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL80066 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL312348 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL120821 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL420224 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL115788 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL32190 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL299174 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL23867 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL54792 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL121868 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL53318 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL55727 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL415962 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL23021 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL117750 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL279679 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL121683 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL264548 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL54538 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL137981 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL23416 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL367802 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL121433 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL123043 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL121348 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL84457 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL53903 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL55191 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL35222 | — | IC50 | = | 26.0 | nM | 7.58 |