Assay Detail
Binding
CHEMBL828664
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory concentration against maize histone deacetylase 1-A (class IIa HDAC)
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 6.36 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 9.10 |
| CHEMBL192098 | — | — | 1 | 8.00 |
| CHEMBL370253 | — | — | 1 | 7.40 |
| CHEMBL142441 | — | — | 1 | 7.30 |
| CHEMBL145116 | — | — | 1 | 7.22 |
| CHEMBL371806 | — | — | 1 | 7.00 |
| CHEMBL192870 | — | — | 1 | 6.80 |
| CHEMBL415533 | — | — | 1 | 6.77 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.75 |
| CHEMBL145685 | — | — | 1 | 6.72 |
| CHEMBL365535 | — | — | 1 | 6.68 |
| CHEMBL191852 | — | — | 1 | 6.66 |
| CHEMBL191089 | — | — | 1 | 6.66 |
| CHEMBL192199 | — | — | 1 | 6.41 |
| CHEMBL145028 | — | — | 1 | 6.36 |
| CHEMBL356769 | TUBACIN | — | 1 | 6.35 |
| CHEMBL145099 | — | — | 1 | 6.30 |
| CHEMBL365372 | — | — | 1 | 6.11 |
| CHEMBL191623 | — | — | 1 | 6.10 |
| CHEMBL364970 | — | — | 1 | 5.80 |
| CHEMBL189381 | — | — | 1 | 5.66 |
| CHEMBL371779 | — | — | 1 | 5.03 |
| CHEMBL192533 | — | — | 1 | 4.80 |
| CHEMBL145531 | — | — | 1 | 4.73 |
| CHEMBL192960 | — | — | 1 | 4.69 |
| CHEMBL192557 | — | — | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL192098 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL370253 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL142441 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL145116 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL371806 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL192870 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL415533 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL145685 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL365535 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL191852 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL191089 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL192199 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL145028 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL356769 | TUBACIN | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL145099 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL365372 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL191623 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL364970 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL189381 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL371779 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL192533 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL145531 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL192960 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL192557 | — | IC50 | = | 90000.0 | nM | 4.05 |