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Assay Detail

CHEMBL828665

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Binding
Inhibitory concentration against maize histone deacetylase 1-B (class I HDAC)
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides.
Mai A, Massa S, Pezzi R, Simeoni S, Rotili D, Nebbioso A, Scognamiglio A, Altucci L, Loidl P, Brosch G.
J Med Chem (2005) 48 : 3344 -3353
PubMed 15857140 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 26 5.87 9.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL99 TRICHOSTATIN 1.0 1 9.40
CHEMBL98 VORINOSTAT 4.0 1 7.52
CHEMBL192870 1 6.77
CHEMBL365535 1 6.75
CHEMBL145685 1 6.58
CHEMBL192098 1 6.48
CHEMBL145116 1 6.41
CHEMBL365372 1 6.24
CHEMBL192199 1 6.22
CHEMBL191623 1 6.10
CHEMBL356769 TUBACIN 1 6.01
CHEMBL364970 1 5.96
CHEMBL142441 1 5.80
CHEMBL370253 1 5.75
CHEMBL415533 1 5.60
CHEMBL371806 1 5.47
CHEMBL191852 1 5.35
CHEMBL145099 1 5.32
CHEMBL192960 1 4.61
CHEMBL192533 1 4.60
CHEMBL145531 1 4.53
CHEMBL189381 1 4.50
CHEMBL145028 1 4.50
CHEMBL191089 1 4.41
CHEMBL371779 1 -
CHEMBL192557 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL99 TRICHOSTATIN IC50 = 0.4 nM 9.40
CHEMBL98 VORINOSTAT IC50 = 30.0 nM 7.52
CHEMBL192870 IC50 = 170.0 nM 6.77
CHEMBL365535 IC50 = 180.0 nM 6.75
CHEMBL145685 IC50 = 260.0 nM 6.58
CHEMBL192098 IC50 = 330.0 nM 6.48
CHEMBL145116 IC50 = 390.0 nM 6.41
CHEMBL365372 IC50 = 570.0 nM 6.24
CHEMBL192199 IC50 = 600.0 nM 6.22
CHEMBL191623 IC50 = 800.0 nM 6.10
CHEMBL356769 TUBACIN IC50 = 980.0 nM 6.01
CHEMBL364970 IC50 = 1100.0 nM 5.96
CHEMBL142441 IC50 = 1600.0 nM 5.80
CHEMBL370253 IC50 = 1800.0 nM 5.75
CHEMBL415533 IC50 = 2500.0 nM 5.60
CHEMBL371806 IC50 = 3400.0 nM 5.47
CHEMBL191852 IC50 = 4500.0 nM 5.35
CHEMBL145099 IC50 = 4800.0 nM 5.32
CHEMBL192960 IC50 = 24300.0 nM 4.61
CHEMBL192533 IC50 = 24900.0 nM 4.60
CHEMBL145531 IC50 = 29400.0 nM 4.53
CHEMBL189381 IC50 = 31800.0 nM 4.50
CHEMBL145028 IC50 = 31400.0 nM 4.50
CHEMBL191089 IC50 = 38800.0 nM 4.41
CHEMBL371779 IC50 = 159000.0 nM -
CHEMBL192557 IC50 = 298000.0 nM -