Assay Detail
Binding
CHEMBL828694
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In vitro inhibitory concentration against histone deacetylase of DU-145 prostate cell nuclear extract as deacetylation of biotinylated [3H]-acetyl histone H4 peptide
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | prostate |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.99 | 7.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL191482 | AR-42 | 2.0 | 1 | 7.80 |
| CHEMBL189137 | — | — | 1 | 7.60 |
| CHEMBL191091 | — | — | 1 | 7.52 |
| CHEMBL188270 | — | — | 1 | 7.47 |
| CHEMBL143336 | — | — | 1 | 7.36 |
| CHEMBL189929 | — | — | 1 | 7.27 |
| CHEMBL189497 | — | — | 1 | 7.17 |
| CHEMBL191483 | — | — | 1 | 7.08 |
| CHEMBL190727 | — | — | 1 | 7.01 |
| CHEMBL189912 | — | — | 1 | 6.96 |
| CHEMBL356824 | — | — | 1 | 6.80 |
| CHEMBL191227 | — | — | 1 | 6.68 |
| CHEMBL190014 | — | — | 1 | 6.60 |
| CHEMBL347734 | — | — | 1 | 6.28 |
| CHEMBL190359 | — | — | 1 | 6.28 |
| CHEMBL142048 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL191482 | AR-42 | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL189137 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL191091 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL188270 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL143336 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL189929 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL189497 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL191483 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL190727 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL189912 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL356824 | — | IC50 | = | 157.0 | nM | 6.80 |
| CHEMBL191227 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL190014 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL347734 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL190359 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL142048 | — | IC50 | = | 1200.0 | nM | 5.92 |