Assay Detail
Binding
CHEMBL828695
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory concentration against human CYP11B2 expressed in V79MZh hamster fibroblasts incubated with 100 nM of substrate deoxy-corticosterone in presence of the compound
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 64 | 7.63 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9298 | FADROZOLE | 2.0 | 1 | 9.00 |
| CHEMBL193555 | — | — | 1 | 8.52 |
| CHEMBL365314 | — | — | 1 | 8.52 |
| CHEMBL371742 | — | — | 1 | 8.40 |
| CHEMBL383145 | — | — | 1 | 8.30 |
| CHEMBL195354 | — | — | 1 | 8.30 |
| CHEMBL194928 | — | — | 1 | 8.22 |
| CHEMBL195248 | — | — | 1 | 8.22 |
| CHEMBL193997 | — | — | 1 | 8.15 |
| CHEMBL192077 | — | — | 1 | 8.10 |
| CHEMBL175962 | — | — | 1 | 8.10 |
| CHEMBL370317 | — | — | 1 | 8.05 |
| CHEMBL176287 | — | — | 1 | 8.05 |
| CHEMBL193858 | — | — | 1 | 7.96 |
| CHEMBL383806 | — | — | 1 | 7.96 |
| CHEMBL195688 | — | — | 1 | 7.89 |
| CHEMBL195580 | — | — | 1 | 7.85 |
| CHEMBL371275 | — | — | 1 | 7.85 |
| CHEMBL424960 | — | — | 1 | 7.82 |
| CHEMBL360026 | — | — | 1 | 7.82 |
| CHEMBL192155 | — | — | 1 | 7.77 |
| CHEMBL175554 | — | — | 1 | 7.75 |
| CHEMBL179149 | — | — | 1 | 7.75 |
| CHEMBL371509 | — | — | 1 | 7.70 |
| CHEMBL366490 | — | — | 1 | 7.68 |
| CHEMBL381194 | — | — | 1 | 7.66 |
| CHEMBL175979 | — | — | 1 | 7.66 |
| CHEMBL193606 | — | — | 1 | 7.66 |
| CHEMBL366773 | — | — | 1 | 7.62 |
| CHEMBL370281 | — | — | 1 | 7.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9298 | FADROZOLE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL193555 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL365314 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL371742 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL383145 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL195354 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL194928 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL195248 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL193997 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL192077 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL175962 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL370317 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL176287 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL193858 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL383806 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL195688 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL195580 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL371275 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL424960 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL360026 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL192155 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL175554 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL179149 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL371509 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL366490 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL381194 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL193606 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL175979 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL366773 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL370281 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL176101 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL383807 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL175791 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL179144 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL195653 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL369623 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL176609 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL175799 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL194440 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL175609 | — | IC50 | = | 55.0 | nM | 7.26 |
| CHEMBL193496 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL179222 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL370530 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL362441 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL359942 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL363849 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL193652 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL425323 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL157101 | KETOCONAZOLE | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL363621 | — | IC50 | = | 92.0 | nM | 7.04 |