Assay Detail
Binding
CHEMBL828749
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of [3H]17-beta-estradiol binding to rat ER beta expressed in Escherichia coli
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Design and synthesis of aryl diphenolic azoles as potent and selective estrogen receptor-beta ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 8.29 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL188528 | — | — | 1 | 8.92 |
| CHEMBL135 | ESTRADIOL | 4.0 | 1 | 8.77 |
| CHEMBL187207 | — | — | 1 | 8.70 |
| CHEMBL187392 | — | — | 1 | 8.66 |
| CHEMBL450940 | PRINABEREL | 2.0 | 1 | 8.50 |
| CHEMBL186513 | — | — | 1 | 8.40 |
| CHEMBL187673 | — | — | 1 | 7.70 |
| CHEMBL188230 | — | — | 1 | 7.54 |
| CHEMBL188882 | — | — | 1 | 7.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL188528 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL135 | ESTRADIOL | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL187207 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL187392 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL450940 | PRINABEREL | IC50 | = | 3.14 | nM | 8.50 |
| CHEMBL186513 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL187673 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL188230 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL188882 | — | IC50 | = | 36.0 | nM | 7.44 |